Current diagnosis and management of primary sclerosing cholangitis
نویسندگان
چکیده
منابع مشابه
Current diagnosis and management of primary sclerosing cholangitis.
Primary sclerosing cholangitis (PSC) is an important liver disease with major morbidity and mortality. The diagnosis of PSC is confirmed by magnetic resonance cholangiopancreaticography, and endoscopic retrograde cholangiopancreaticography is performed in patients needing therapeutic endoscopy. As a result of the unknown cause of the disease, current medical therapies are unsatisfactory. Nevert...
متن کاملCurrent management of primary biliary cirrhosis and primary sclerosing cholangitis.
Primary biliary cirrhosis (PBC) is a chronic, cholestatic autoimmune liver disease characterized by inflammation and progressive destruction of interlobular bile ducts, ultimately leading to biliary cirrhosis. Population based studies have estimated the incidence of PBC as 19.1–251/ 1 000 000 in the general population [1,2]. The etiology of PBC is attributed to autoimmunity mainly due to the as...
متن کاملAASLD PRACTICE GUIDELINES Diagnosis and Management of Primary Sclerosing Cholangitis
Preamble This guideline has been approved by the American Association for the Study of Liver Diseases and represents the position of the Association. These recommendations provide a data-supported approach. They are based on the following: (1) formal review and analysis of the recentlypublished world literature on the topic (Medline search); (2) American College of Physicians Manual for Assessi...
متن کاملPrimary sclerosing cholangitis: diagnostic and management challenges
Primary sclerosing cholangitis (PSC) is a chronic immune-mediated disease affecting intra- and extrahepatic bile ducts, primarily the large biliary ducts. Clinical manifestations are broad, and the spectrum encompasses asymptomatic cholestasis, icteric cholangitis with pruritis, cirrhosis, and cholangiocarcinoma. Though rare, PSC has a propensity to affect young to middle-aged males and is stro...
متن کاملPrimary sclerosing cholangitis: etiopathogenesis and clinical management.
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease characterized by the destruction of medium to large-sized bile ducts and intense, concentric fibrosis. Complications from PSC include bacterial cholangitis, cirrhosis, and cholangiocarcinoma and a therapy that might alter the natural history of the disease remains lacking. Our understanding of the pathogenesis of PSC a...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2008
ISSN: 1527-6465,1527-6473
DOI: 10.1002/lt.21456